Brian Coombes, PhD
Professor and Chair, Department of Biochemistry and Biomedical Sciences
(905) 525-9140 x 22454
Health Sciences Centre (HSC) 4N59
Tier 2 Canada Research Chair in Infectious Disease Pathogenesis
The Coombes lab develops pre-clinical infection models to study the efficacy of novel antibiotics, chemical combinations, and antibiotic adjuvants discovered in high-throughput screening. They are also addressing the antimicrobial resistance crisis by looking at ways to enhance the effectiveness of innate immunity, and by understanding host-pathogen interactions that dictate infection outcome.
Structural–Functional Studies of Burkholderia cenocepacia d-Glycero-β-d-manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties (2013)